Evaluation of in vitro dissolution similarity of bisoprolol film-coated tablets based on Weibull modelling using MATLABTM simulation software

The aim of this study was to compare the in vitro dissolution behaviour reference (R) and generic-test (T) medicinal products with non-linear effects model. Mathematical function Weibull, employed as basis for model, coupled MATLABTM simulation software describe release profile active substance. Medicinal selected presented include immediate-release tablets Concor 10 mg Bisoprolol mg, which belongs BCS class 1 biopharmaceutics classification system. result from indicated that Weibull distribution computer-based program is more useful comparison profiles. This combined approach provides robust informative results, accurate estimation on performance it’s most suitable tool prediction vivo product. In summary, we have Simulink graphical programming design our system a environment.